Genetic vulnerability and adverse mental health outcomes following mild Traumatic Brain Injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts.

Authors:

Mart Kals, Lindsay Wilson, Daniel F Levey, Livia Parodi, Ewout W Steyerberg , Sylvia Richardson, Feng He, Xiaoying Sun, Sonia Jain, Aarno Palotie, Samuli Ripatti, Jonathan Rosand, Geoff T Manley, Andrew I R Maas, Murray B Stein, David K Menon; Genetic Associations In Neurotrauma (GAIN) Consortium (with contribution from the CENTER-TBI and TRACK-TBI studies).

Lay summary – PTSD and depression are common after a mild traumatic brain injury, but we do not fully understand why some people develop these problems. This study looked at whether a person’s genetic risk for PTSD or depression could help predict who is more likely to develop related symptoms after a mild brain injury.