Mendelian randomization analysis of the IL-1 cytokine family proteins identifies IL1RL1 as a potential causal contributor to Traumatic Brain Injury prognosis.

Authors:

Youngjune Bhak, Adel Helmy, Edward J Needham, David K Menon, Varun Warrier, Romit J Samanta & the CENTER TBI Study Consortium.

Lay summary – Traumatic brain injury (TBI) is a leading preventable cause of death and disability worldwide. Inflammatory mechanisms contribute to secondary brain injury, and the interleukin-1 (IL-1) cytokine family has emerged as a potential contributor. However, whether circulating IL-1-family cytokines causally influence TBI outcomes remains unknown.