Parsimonious immune-response endotypes and global outcome in patients with Traumatic Brain Injury.

Authors:

Romit J. Samanta, Anne-Cécile Chiollaz, Edward Needham, John K. Yue, Adel Helmy, Elisa R. Zanier, Kevin K.W.Wang, Firas Kobeissy,
Jussi P. Posti, Charlotte Summers, Geoffrey T.Manley, AndrewIR.Maas, Olli Tenovuo, Jean-Charles Sanchez, and David K.Menon, on behalf
of the TRACK-TBI investigators and participants CENTER-TBI investigators and participantsm.

Lay summary – Inflammation after traumatic brain injury may help doctors identify different patient groups and develop more targeted treatments. Previous treatments that tried to change the immune response in all TBI patients have not improved outcomes, suggesting that future treatments may need to be tailored to individual patients.